This is the most versatile string set I've tried from Ernie Ball. It's also my current favourite set on the planet! I use a lot of different tunings on very different guitars and it kills it on all of them.
I play metal and use the 2627 Beefy Slinky string set for E Standard, Open E, Drop D, Drop C and Drop B. It also has one of the longest lifespans, that I've personally encountered.
As for the sound: it never seems to lose its brilliance and bite, right up until string breakage. Rare indeed.
Highly recommend this string set for anyone who plays downtuned music or needs high tension in more standard tunings.