I have used these strings for C standard tuning, and drop Hb as well. For the feel of 10-46 string tension for your drop tuning I would recommend C# as the highest tuning, but it can be done.
They are really thick and clear sounding for clean playing but they also roar when you put on some distortion. They are well made and always in great packaging.
The only thing I find could be improved is the 24p string, it has a slight different sound than the other thinner strings, which is more noticable when playing clean than with distortion. This can be ignored but if you are really strict with your sound you might want to look for a replacement for the 24p. But overall they feel and sound great!