The Hyper Slinky set is now my favourite set, for tuning in E Standard.
I used to use the Hybrid Slinky set (Orange Pack) on 25.5" scale guitars.
After 4 gigs in a weekend, I ended up with a pain in my ring finger which lasted for around 5 weeks. I ended up having to stop playing for 4 weeks for the pain to finally go away.
I went down to 8's (Extra Slinky blue set) which was great for soloing and meant no pain whatsoever. Although, It was just too slinky for me with the rhythm playing. I wasn't able to dig in when I needed to, for picking hand dynamics, without the odd bit of noticeable tunning issues.
This set is the perfect balance. Solid and stable on the low strings and plays like a dream for soloing.
Holds tuning very well, on a well setup guitar.
With Ernie Ball Wonder Wipes String Cleaner, and a wipe down with tissue paper before a gig, I get 4 gigs out of them before I feel the need to change but I'm sure they could last a longer without a string snap.